Fresh Hemorrhages in Intestinal Resection Margins Are Associated with Unfavorable Clinical Outcomes in Preterm Infants with Necrotizing Enterocolitis with Surgical Intervention

This retrospective study shows a significant correlation between a fresh hematoma in the tissue of the resection margin and the clinical prognosis. Fresh bleeding in the resection margins was associated with increased morbidity with stenosis and possibly another surgical intervention. In contrast, no further correlation was found between the vitality of the tunica mucosae, the tunica muscularis or peritonitis in the resection margin or central part of the NEC specimen and the clinical course. In summary, it can be said that the presence of a fresh hematoma at the resection margin is significantly linked to a poorer clinical outcome for the infants with NEC surgery. Other histopathological findings of the surgical specimen with regard to the clinical course show now significant correlation and, therefore, the histological examination mainly serves the medico-legal documentation and quality assurance of the NEC operation.