Attenuation of Hypertension and protection of vascular inflammation in hyperaldosteronism: GPER1 as potential therapeutic candidate when MR antagonist is less satisfying?
We discovered attenuation of hypertension and vascular inflammation of GPER1 KO mice only on the basis of mineralocorticoid receptor (MR) blocking. Collectively, our study indicates that GPER1 might become a therapeutic target of hyperaldosteronism in controlling the residual risk of cardiovascular disease when MR antagonist alone is not satisfying.
Authors
- Ziwei Tang (ORCID: https://orcid.org/0000-0002-7560-5528)
- Qinglian Zeng (ORCID: https://orcid.org/0009-0006-5933-7953)
- Xing‐Qiu Chen (ORCID: https://orcid.org/0000-0002-5904-6578)
- Qingfeng Cheng (ORCID: https://orcid.org/0000-0001-8676-5597)
- Wenwen He (ORCID: https://orcid.org/0000-0003-4442-1707)
- Xun Li (ORCID: https://orcid.org/0000-0002-5070-8950)
- Yu Xia (ORCID: https://orcid.org/0000-0002-4571-6075)
- Mei Mei (ORCID: https://orcid.org/0000-0002-2177-5839)
- Zhipeng Du (ORCID: https://orcid.org/0009-0006-2071-2293)
- Yulian Lai
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Endocrine
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1007/s12020-024-04106-6
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chongqing Medical University