Prognostic Role of Invasion-Related Extracellular Matrix Molecules in Diffusely Infiltrating Grade 2 and 3 Astrocytomas
Based on the invasion spectrum determined by this joint gene and protein expression analysis, there was a sensitivity of 87.5% and a negative predictive value of 88.9% regarding the different prognostic groups of grade 2 astrocytoma. For grade 3 tumors, the applied standard oncotherapeutic modalities apparently lacked significant anti-invasive effects.
Authors
- AB Abani Bako
- Gábor Zahuczki
- Álmos Klekner (ORCID: https://orcid.org/0000-0003-2887-8918)
- József Virga (ORCID: https://orcid.org/0000-0002-0691-7800)
- László Szívos (ORCID: https://orcid.org/0000-0001-8746-3726)
- Tibor Hortobágyi (ORCID: https://orcid.org/0000-0001-5732-7942)
- Zoltán Mészár (ORCID: https://orcid.org/0000-0001-5032-8520)
- Melinda Rostás
Institutions
- University of Debrecen (HU)
- University of Szeged (HU)
- University Hospital of Zurich (CH)
- UD-GenoMed (Hungary) (HU)
Publication Details
- Journal
- Brain Sciences
- Published
- 2024-11-20
- DOI
- https://doi.org/10.3390/brainsci14111157
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Szegedi Tudományegyetem
- Medical Research Council