Population Pharmacokinetics of Ensitrelvir in Healthy Participants and Participants with SARS-CoV-2 Infection in the SCORPIO-SR Study
Population pharmacokinetics revealed that body weight is the most important covariate in the pharmacokinetics of ensitrelvir. The antiviral effect, independent of ensitrelvir exposure, was demonstrated on the current dose regimen for treatment of SARS-CoV-2 infection.
Authors
- Ryosuke Shimizu (ORCID: https://orcid.org/0000-0001-9666-8678)
- Ryuji Kubota (ORCID: https://orcid.org/0000-0003-1979-4472)
- Tôru Ishibashi (ORCID: https://orcid.org/0000-0003-3383-9980)
Institutions
- Shionogi (Japan) (JP)
- Futaba (Japan) (JP)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1007/s40262-024-01446-4
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shionogi