Sustainable Spectrophotometric Quantification of Lansoprazole Through Mixed Hydrotropy Approach

Solubility is the property of a substance to dissolve in or form a homogeneous mixture with another substance. One of the most common problems associated with making a solution is poor solubility. There are many drugs that are sparingly soluble or insoluble in water, and lansoprazole is one of them. Aqueous solubility of lansoprazole is 0.05 mg/ml at room temperature. The current study aims to improve lansoprazole solubility using a mixed hydrotropy method. The purpose of the mixed hydrotropic solubilization approach is to increase the solubility of weakly water-soluble drugs in hydrotropic agent blends. To avoid the use of organic solvents, the mixed hydrotropy idea may be a good option. In this current research attempt, a novel method for spectrophotometric estimation of lansoprazole using a mixed solvent blend (containing 10% SC and 20% SB) as the solvent was developed. By observing the absorbances of the drug's standard solutions, the calibration curve for lansoprazole was drawn. The absorbances were measured at 275 nm compared to the corresponding reagent blanks. The percent label claims were found to be very near to 100, showing that the proposed approach is accurate. The suggested method estimates percent recoveries to be near 100 with significantly low percentage deviation and standard error values. As a result, the proposed process is simple, safe, and precise, and it does not require the use of harmful chemical solvents.