Association between osteoprotegerin and RANKL single nucleotide polymorphisms and destructive rhinosinusitis in patients with granulomatosis with polyangiitis
SNPs in osteoprotegerin G1181C and RANKL A290G may play a role in the development of destructive rhinosinusitis in patients with GPA. Genetic assessment may be useful for identifying high-risk individuals. This observational study might work as a basis for further research to better understand this association and clinical trials using RANKL/osteoprotegerin as therapeutic targets.
Authors
- Diogo Souza Domiciano (ORCID: https://orcid.org/0000-0001-7991-0231)
- Carmen Sílvia Valente Barbas (ORCID: https://orcid.org/0000-0002-3922-6256)
- Samuel Katsuyuki Shinjo (ORCID: https://orcid.org/0000-0002-3682-4517)
- Marilia Ambiel Dagostin (ORCID: https://orcid.org/0000-0002-3203-768X)
- Rosa Maria Rodrigues Pereira (ORCID: https://orcid.org/0000-0002-3723-5028)
- Henrique A. M. Giardini
- Valéria F. Caparbo (ORCID: https://orcid.org/0000-0002-6606-8628)
- Bidossessi Wilfried Hounkpe (ORCID: https://orcid.org/0000-0002-9992-1939)
Institutions
- Faculdade de Medicina de Marília (BR)
- Universidade de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- BMC Rheumatology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s41927-024-00434-2
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico