Comparison Between Different Source Localization and Connectivity Metrics of Spiky and Oscillatory MEG Activities

Epilepsy is considered the second neurological disease in a coma after stroke. Famous markers of epilepsy are repetitive seizures, their origin is stroma and cortical deformation. A neurologist would be assisted by identifying Epileptogenic Zones EZ when diagnosing epilepsy.. Source localization is utilized to identify regions known as EZ, which are of excessive discharges. It consists of both forward and inverse problems. The forward problem models the head through analytical and numerical methods. The inverse problem can be resolved using several techniques to locate the cerebral abnormal sources, via the electrophysiological recording biomarkers. In our study, we will investigate four distributed inverse problem methods: minimum norm estimation MNE, standardized low-resolution brain electromagnetic tomography sLORETA, maximum entropy on the mean MEM, Dynamic statistical parametric maps dSPM, to define epileptic networks connectivity of spiky and oscillatory events. We will examine the epileptic network connectivity using Phase Locking Value (PLV), Phase Transfert Entropy (PTE) for oscillatory events, cross-correlation (CC), and Granger Causality (GC) for spiky events applied on 5 pharmaco resistant subjects. We suggest rating the effectiveness of these networks in locating EZ through a phase of confrontation within iEEG transitory and oscillatory networks connectivity by exploring concordant nodes, their distance, propagation delays connection strength, and their cooperation in recognition of seizure onset zone. All studied techniques of the inverse problem, connection metrics, for both biomarkers of the 5 patients succeed in detecting at least one part of SOZ. sLORETA provides the highest concordant nodes and the closed one for spiky events using CC and GC. sLORETA also depicts the lowest propagation delay for oscillatory events using PTE. Through the 5 patients, MEM, dSPM, and MNE using CC, CG for spiky events, and PTE, PLV for oscillatory activities provide about 72 % of concordant nodes between MEG and iEEG.