Proteoglycans Enhance the Therapeutic Effect of BMSC Transplantation on Osteoarthritis
PG enhances BMSC differentiation into chondrocytes and stimulates paracrine TGF-β1 secretion. Proteoglycans not only promote chondrocyte differentiation and paracrine TGF-β1 signaling in BMSCs but also increase the sensitivity of chondrocytes to TGF-β1 secreted from BMSCs, leading to PRG4 expression through the TGFR/Smad2/3 pathway. Proteoglycans can enhance the therapeutic effect of BMSC treatment on OA and have the potential to delay the degeneration of OA cartilage.
Authors
- Dewei Zhao (ORCID: https://orcid.org/0000-0001-7914-6288)
- Weidan Wang (ORCID: https://orcid.org/0000-0001-6051-4888)
- Tianhao Liu (ORCID: https://orcid.org/0000-0003-4066-5034)
- Yongming Bao (ORCID: https://orcid.org/0000-0003-0866-8630)
- Chunxiao Ran
- Guangxiao Yin (ORCID: https://orcid.org/0000-0001-8932-3989)
- Xiuzhi Zhang (ORCID: https://orcid.org/0000-0003-2854-9938)
- Dong Xue (ORCID: https://orcid.org/0000-0002-7969-7386)
Institutions
- Dalian University of Technology (CN)
- Dalian University (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- Bioengineering
- Published
- 2024-11-20
- DOI
- https://doi.org/10.3390/bioengineering11111167
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Education of Liaoning Province