Inhibition of PA28γ expression can alleviate osteoarthritis by inhibiting endoplasmic reticulum stress and promoting STAT3 phosphorylation
PA28γ knockdown in chondrocytes can inhibit anabolic and catabolic dysregulation, inflammatory response, and apoptosis in OA. Moreover, PA28γ knockdown in chondrocytes can inhibit ER stress by promoting STAT3 phosphorylation.
Authors
- Fengjing Guo (ORCID: https://orcid.org/0000-0002-5968-4836)
- Kai Sun (ORCID: https://orcid.org/0009-0003-5746-4615)
- Zhaoxuan Ruan (ORCID: https://orcid.org/0009-0006-4652-1735)
- Zhiyi He (ORCID: https://orcid.org/0000-0001-7215-1682)
- Haokun Mo (ORCID: https://orcid.org/0000-0002-8751-5271)
- Haigang Liu (ORCID: https://orcid.org/0009-0004-7257-8474)
- Yanjun Hou
- Zhenggang Wang (ORCID: https://orcid.org/0000-0002-0185-4951)
- Liang Li (ORCID: https://orcid.org/0000-0002-6694-1546)
Institutions
- Wuhan National Laboratory for Optoelectronics (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1302/2046-3758.1311.bjr-2023-0361.r2
- Citations
- 3
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Natural Science Foundation of China