Kinetics of the inhibition and recovery of spermatogenesis induced by treatment with WIN 18,446, a male contraceptive, in mice
Effects of ALDH1A inhibition on spermatogenesis are reversible. Our observation that strong inhibition of ALDH1A disrupts the seminiferous epithelium prior to the completion of a full cycle of spermatogenesis suggests that episodic inhibition of ALDH1A may function as a male contraceptive.
Authors
- John K. Amory (ORCID: https://orcid.org/0000-0002-7419-435X)
- Michael Haenisch
- Jisun Paik (ORCID: https://orcid.org/0000-0001-5628-7723)
- Jessica M. Snyder (ORCID: https://orcid.org/0000-0002-0470-0931)
- Andy Kim (ORCID: https://orcid.org/0000-0001-6551-2881)
- Kevin Fogassy
Institutions
- University of Washington (US)
Publication Details
- Journal
- Andrology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1111/andr.13807
- Citations
- 2
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Institutes of Health