Hepatic and pulmonary macrophage activity in a mucosal challenge model of Ebola virus disease
These data demonstrate that hepatic macrophages in terminal conjunctivally challenged cynomolgus macaques may express a unique inflammatory profile compared to other macaque models and that macrophage-related pharmacologically druggable targets are expressed in both the liver and the lung in Ebola virus disease.
Authors
- Timothy G. Wanninger
- Esteban Arroyave (ORCID: https://orcid.org/0000-0002-4996-1094)
- Slobodan Paessler (ORCID: https://orcid.org/0000-0002-2213-9551)
- Daniel Millián (ORCID: https://orcid.org/0000-0002-9661-7165)
- Jason E. Comer (ORCID: https://orcid.org/0000-0001-7471-9905)
- Ómar A. Saldarriaga (ORCID: https://orcid.org/0000-0001-7822-108X)
- Heather L. Stevenson (ORCID: https://orcid.org/0000-0002-0645-7621)
Institutions
- Louisiana State University (US)
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.3389/fimmu.2024.1439971
- Citations
- 1
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Centers for Disease Control and Prevention