Immune checkpoint inhibitor‐induced pancreatic enzyme elevation in melanoma patients: Incidence, management and therapy—A multicentre analysis
Routine lipase monitoring was conducted in all participating centres, although not recommended in respective guidelines. Elevation of serum lipase was observed more frequently than recently reported. Although radiographic findings indicating pancreatitis were rare in asymptomatic patients, ICI treatment was frequently paused or discontinued and systemic steroids were administered. To reduce the existing uncertainty in routine clinical practice reflected by our findings, we provide an algorithm to guide the monitoring and management of potential pancreatic adverse events. Lipase measurement should be limited to symptomatic patients and/or those with radiographic findings indicative of pancreatic injury.
Authors
- Kim A. Reiss (ORCID: https://orcid.org/0000-0003-0774-9914)
- Wolfgang Hitzl (ORCID: https://orcid.org/0000-0002-7696-1479)
- Erika Richtig (ORCID: https://orcid.org/0000-0002-5505-6103)
- Florian Froehlich (ORCID: https://orcid.org/0009-0001-3109-0198)
- Magdalena Hoellwerth (ORCID: https://orcid.org/0000-0002-2771-4041)
- Matthias Brandlmaier (ORCID: https://orcid.org/0009-0004-0210-5065)
- T. Silly
- Peter Koelblinger (ORCID: https://orcid.org/0000-0002-5897-2780)
- M Bárta
- Christoph Höeller (ORCID: https://orcid.org/0000-0003-1192-0227)
- Bernhard Lange‐Asschenfeldt
- M. Schmid‐Simbeck
- Lukas Koch (ORCID: https://orcid.org/0000-0003-2091-5411)
- Reinhard Dummer (ORCID: https://orcid.org/0000-0002-2279-6906)
- L. Muigg
Institutions
- Paracelsus Medical University (AT)
- Donauspital (AT)
- Fachhochschule Wiener Neustadt (AT)
- Klinikum Klagenfurt (AT)
- University Hospital of Zurich (CH)
- Klinikum Wels-Grieskirchen (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Journal of the European Academy of Dermatology and Venereology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1111/jdv.20384
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85