Hybridization of polyoxometalates and metal-organic frameworks for effective tumor chemodynamic therapy and sonodynamic therapy

Metal-organic frameworks (MOFs) with high porosity, specific surface area, and unique topologies are highly regarded for their applications in photocatalysis, medical treatment, and environmental pollutant degradation. However, due to the limitations of the tumor microenvironment (TME), traditional MOFs have limited efficacy in this environment. This paper designs multi-metal oxide-based heterostructure POMOFs nanoreactors with a nesting doll-like structure. This new structure not only exhibits therapeutic effects in TME but also utilizes ultrasound (US) to enhance the release of reactive oxygen species (ROS) for CDT&SDT co-therapy, becoming an effective sound sensitizer for destroying tumor cells. In summary, our study proposes an idea for constructing multi-metal oxide-based heterostructure MOFs nanoreactors material with a nesting doll-like structure to enhance ROS release and synergistically treat tumor diseases.