Cytotoxic properties of <i>Thuya occidentalis</i> hydroalcoholic extract on androgen unresponsive prostate cancer cells
<b>Results:</b> <i>T. occidentalis</i> and α-thujone showed the highest cytotoxicity on LNCaP cells. In androgen unresponsive cells, <i>T. occidentalis</i> decreased cell viability and density, and promoted apoptosis, necrosis and cell cycle arrest, possibly associated with Cav-1 downregulation. The α-thujone present in the extract significantly LNCaP cells density, but did not affect DU145 and PC3 cells, suggesting that other compounds may also be cytotoxic to androgen unresponsive cells.
Authors
- Tatiana Emanuelli (ORCID: https://orcid.org/0000-0003-0168-3416)
- Róger Wagner (ORCID: https://orcid.org/0000-0002-6176-7913)
- Lílian Corrêa Costa‐Beber (ORCID: https://orcid.org/0000-0001-7796-1641)
- Fátima Theresinha Costa Rodrigues Guma (ORCID: https://orcid.org/0000-0003-2369-7739)
- Tassiane dos Santos Ferrão (ORCID: https://orcid.org/0000-0003-0824-7094)
- Mariana Migliorini Parisi (ORCID: https://orcid.org/0000-0002-2298-7809)
- Cláudia Marlise Balbinotti Andrade (ORCID: https://orcid.org/0000-0003-2765-3717)
- Gabriela Elisa Hirsch (ORCID: https://orcid.org/0000-0001-5815-2347)
- Léo Anderson Meira Martins (ORCID: https://orcid.org/0000-0003-0878-0489)
- Sílvia Resende Terra
- Florencia Mária Barbé Tuana
Institutions
- University of Cruz Alta (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Instituto Federal de Educação, Ciência e Tecnologia de Mato Grosso (BR)
- Universidade Federal de Mato Grosso (BR)
- Universidade Federal de Santa Maria (BR)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- University of Rio Grande and Rio Grande Community College (US)
Publication Details
- Journal
- Archives of Physiology and Biochemistry
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1080/13813455.2024.2430488
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00