Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice
Short-term FMD causes more pronounced changes in blood parameters and slightly higher weight loss than IF, while both activate similar pathways (particularly PPARα signalling) in the liver. On individual gene level FMD induces a stronger transcriptional response, whereas cyclic application blunts transcriptional upregulation of fatty acid oxidation and ketogenesis only in FMD. Hence, our comparative characterization of IF and FMD protocols renders both as effective DR regimens and serves as resource in the fasting research field.
Authors
- Sarah Stryeck (ORCID: https://orcid.org/0000-0001-7524-6038)
- Helene Michenthaler (ORCID: https://orcid.org/0000-0002-3530-0498)
- Kalina Duszka (ORCID: https://orcid.org/0000-0002-7455-6090)
- Markus Galhuber
- Tobias Madl (ORCID: https://orcid.org/0000-0002-9725-5231)
- Isabel Reinisch (ORCID: https://orcid.org/0000-0002-3587-4635)
- Elisabeth Moyschewitz
- Andreas Prokesch (ORCID: https://orcid.org/0000-0002-8487-7103)
- Jelena Krstić (ORCID: https://orcid.org/0000-0002-3423-533X)
Institutions
- University of Vienna (AT)
- Universität Innsbruck (AT)
- Medical University of Graz (AT)
- ETH Zurich (CH)
- Graz University of Technology (AT)
- BioTechMed-Graz (AT)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s12915-024-02061-2
- Citations
- 3
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- Austrian Science Fund
- Österreichische Forschungsförderungsgesellschaft
- Karl-Franzens-Universität Graz
- Medizinische Universität Graz
- BioTechMed-Graz