Cancer-associated fibroblasts reveal aberrant DNA methylation across different types of cancer
The activation of CAFs by the tumor microenvironment seems to be associated with distinct epigenetic modifications. Remarkably, similar genomic regions tend to undergo hypomethylation in CAFs across different studies and cancer types. Our findings suggest that CAF-associated DNA methylation changes hold potential as prognostic biomarkers. However, further research and validation are necessary to develop and apply such signatures in a clinical setting.
Authors
- Tiago Maié (ORCID: https://orcid.org/0000-0003-4857-4014)
- Thorsten Cramer (ORCID: https://orcid.org/0000-0002-6462-239X)
- Wolfgang Wagner (ORCID: https://orcid.org/0000-0002-1971-3217)
- Marco Schmidt (ORCID: https://orcid.org/0000-0002-2848-3249)
- Ivan G. Costa (ORCID: https://orcid.org/0000-0003-2890-8697)
Institutions
- RWTH Aachen University (DE)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s13148-024-01783-y
- Citations
- 5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Else Kröner-Fresenius-Stiftung
- Medizinische Fakultät, RWTH Aachen University