Systematic regulation of immune checkpoint molecules by redox regulators CNC-bZIP transcription factors
In this study, the universal and systematic transcriptional regulatory role of the CNC-bZIP transcription factor family on ICMs was discovered. According to this study, the results and conclusions drawn are based on gene expression correlation and promoter activity assays, the CNC-bZIPs/ICMs transcriptional regulatory axis was revealed to be a potential regulatory axis that may drive redox signaling and anti-tumor immune responses.
Authors
- Lu Qiu (ORCID: https://orcid.org/0000-0003-0471-7386)
- Haoming Ning
- Yonggang Ren (ORCID: https://orcid.org/0000-0002-2825-7065)
- Qiufang Yang
Institutions
- North Sichuan Medical University (CN)
- Sun Yat-sen University (CN)
- Shenzhen University (CN)
- Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1007/s12672-024-01574-0
- Citations
- 3
- Primary Topic
- Redox biology and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- China Postdoctoral Science Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province