Allylation of Lactol in Water
We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3<i>H</i>)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.
Authors
- Teck‐Peng Loh (ORCID: https://orcid.org/0000-0002-2936-337X)
- Mengxue Zheng (ORCID: https://orcid.org/0000-0002-2447-6658)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-0100-8357)
- Zhenguo Zhang (ORCID: https://orcid.org/0000-0001-7872-4947)
- Peizhong Xie (ORCID: https://orcid.org/0000-0002-6777-0443)
- Wenxiu Gao (ORCID: https://orcid.org/0000-0002-4962-6501)
- Kaiyu Yan
Institutions
- Nanjing Tech University (CN)
- Tianjin Chengjian University (CN)
- Nanyang Technological University (SG)
- Henan University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1021/acs.orglett.4c04189
- Citations
- 3
- Primary Topic
- Chemical Synthesis and Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Nanyang Technological University
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Six Talent Peaks Project in Jiangsu Province
- Advanced Remanufacturing and Technology Centre