A double knockout for zinc transporter 8 and somatostatin in mice reveals their distinct roles in regulation of insulin secretion and obesity
Somatostatin as well as a normal insulin sensitivity are required for normalizing glucose metabolism in Znt8KO mice. ZnT8 may play a role in regulating fat mass and leptin secretion. These findings shed light on the multifaceted nature of Znt8 and Sst interactions, opening new avenues to understand their roles in controlling glucose metabolism and fat mass.
Authors
- Zhongyue Yang
- Catherine P. Kirschke (ORCID: https://orcid.org/0000-0002-8403-3322)
- Yimeng Cai
- Liping Huang (ORCID: https://orcid.org/0000-0001-8064-5391)
Institutions
- West Health (US)
- Western Human Nutrition Research Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Genes & Nutrition
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s12263-024-00759-0
- Citations
- 2
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- U.S. Department of Agriculture
- University of California, Davis
- Agricultural Research Service