Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetes
This population-level assessment shows secondary complications in individuals with pathogenic and glucose-elevating GCK variants and T2D and suggests that genotyping for these variants should be considered in a precision medicine approach for T2D treatment and prevention.
Authors
- Natalie Telis (ORCID: https://orcid.org/0000-0002-4813-6893)
- Nicole Washington (ORCID: https://orcid.org/0000-0001-8936-9143)
- Basil Khuder (ORCID: https://orcid.org/0000-0002-1012-6198)
- Kelly M. Schiabor Barrett (ORCID: https://orcid.org/0000-0001-6194-787X)
- Alexandre Bolze (ORCID: https://orcid.org/0000-0001-7399-2766)
- Evanette Burrows (ORCID: https://orcid.org/0000-0001-6645-9613)
- Lisa M. McEwen (ORCID: https://orcid.org/0000-0002-0500-9173)
- Pamala A. Pawloski (ORCID: https://orcid.org/0000-0002-1005-5764)
- Joseph J. Grzymski (ORCID: https://orcid.org/0000-0003-2646-8958)
- Daniel Philip Judge (ORCID: https://orcid.org/0000-0002-3407-0248)
- Elizabeth T. Cirulli (ORCID: https://orcid.org/0000-0001-7808-2809)
Institutions
- University of Nevada, Reno (US)
- Medical University of South Carolina (US)
- Renown Health (US)
- Helix (United States) (US)
- HealthPartners (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1038/s43856-024-00663-z
- Citations
- 6
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- University of South Carolina