Ordered assemblies of peptide nanoparticles with only positive charge
Surface charge patchiness of different charge types can influence the solution behaviours of colloidal particles and globular proteins. Herein, coiled-coil 'bundlemer' nanoparticles that display only a single type of surface charge (SC) are computationally designed to compare their solution behaviours to mixed charge-type (MC) counterparts with both positively and negatively charged side chains. Nematic and columnar liquid crystal phases are discovered in low concentrations of SC particles, indicative of particle end-to-end stacking into columns combined with lateral electrostatic repulsion between columns, while MC particles with the same net charge and particle shape produced only amorphous, soluble aggregates. Similarly, porous lattices are formed in mixtures of SC/MC particles of opposite charges while MC/MC mixtures of opposite charges produce only amorphous aggregates. The lattice structure is inferred with a machine learning optimization approach. The differences between SC and MC particle behaviours directly show the importance of surface electrostatic patchiness.
Authors
- Christopher J. Kloxin (ORCID: https://orcid.org/0000-0002-1679-0022)
- Jeffery G. Saven (ORCID: https://orcid.org/0000-0001-5027-7241)
- Yao Tang (ORCID: https://orcid.org/0000-0002-0917-3819)
- Darrin J. Pochan (ORCID: https://orcid.org/0000-0002-0454-2339)
- Tianren Zhang (ORCID: https://orcid.org/0000-0003-2899-5727)
- Rui Guo (ORCID: https://orcid.org/0000-0002-1129-4716)
- Dai-Bei Yang (ORCID: https://orcid.org/0009-0009-3327-6920)
- Zihan Zhang (ORCID: https://orcid.org/0000-0002-5912-2497)
- Yi Shi (ORCID: https://orcid.org/0000-0002-9084-8069)
- Amanda L. McCahill (ORCID: https://orcid.org/0000-0002-4943-2790)
- Sabrina E. Liskey
Institutions
- University of Pennsylvania (US)
- University of Delaware (US)
- Philadelphia University (US)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1038/s41467-024-54340-9
- Citations
- 12
- Primary Topic
- Pickering emulsions and particle stabilization
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- National Science Foundation
- U.S. Department of Energy
- U.S. Department of Commerce
- National Institutes of Health
- National Institute of Standards and Technology
- Office of Science
- National Institute of General Medical Sciences
- Division of Materials Research
- Division of Chemistry
- Basic Energy Sciences
- Biological and Environmental Research
- Brookhaven National Laboratory