Antibiotic resistant bacteria survive treatment by doubling while shrinking
The evolution of antimicrobial resistance poses a pressing challenge to global health with an estimated 5 million deaths associated with antimicrobial resistance every year globally. Here, we investigate the diversity of strategies employed by bacteria to survive antibiotics. We discovered that bacteria evolve genetic resistance to antibiotics while simultaneously displaying tolerance to very high doses of antibiotics by doubling while shrinking in size.
Authors
- Krasimira T. Tsaneva-Atanasova (ORCID: https://orcid.org/0000-0002-6294-7051)
- Adrian Campey (ORCID: https://orcid.org/0000-0003-3527-2965)
- Urszula Łapińska (ORCID: https://orcid.org/0000-0003-3593-9248)
- Stefano Pagliara (ORCID: https://orcid.org/0000-0001-9796-1956)
- Remy Chait (ORCID: https://orcid.org/0000-0003-0876-3187)
Institutions
- Engineering and Physical Sciences Research Council (GB)
- University of Exeter (GB)
- Living Systems (United States) (US)
Publication Details
- Journal
- mBio
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1128/mbio.02375-24
- Citations
- 10
- Primary Topic
- Evolution and Genetic Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 5.50
Funders
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council