Increased potentiation of 5-fluorouracil induced thymidylate synthase inhibition by 5,10-methylenetetrahydrofolate (arfolitixorin) compared to leucovorin in patients with colorectal liver metastases; The Modelle-001 Trial
The Modelle-001 Trial demonstrated significantly higher levels of MeTHF in metastases following Arfo compared to LV. This resulted in a greater increase TS inhibition in metastases although not statistically significant.
Authors
- Helena Taflin (ORCID: https://orcid.org/0000-0002-8795-5250)
- Jacek Turyn (ORCID: https://orcid.org/0000-0003-4909-0214)
- Yvonne Wettergren (ORCID: https://orcid.org/0000-0001-8660-7169)
- Godefridus J. Peters (ORCID: https://orcid.org/0000-0002-5447-2877)
- Oskar Hemmingsson (ORCID: https://orcid.org/0000-0003-1732-168X)
- Krzysztof Urbanowicz (ORCID: https://orcid.org/0000-0001-6645-6893)
- Ryszard T. Smoleński (ORCID: https://orcid.org/0000-0002-0190-9414)
- Bengt Gustavsson
- Göran Carlsson
- Elisabeth Odin (ORCID: https://orcid.org/0009-0006-7123-6418)
Institutions
- Sahlgrenska University Hospital (SE)
- Region Västra Götaland (SE)
- Amsterdam University Medical Centers (NL)
- Gdańsk Medical University (PL)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- Umeå University (SE)
Publication Details
- Journal
- BJC Reports
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1038/s44276-024-00111-4
- Citations
- 7
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- Cancerfonden
- Göteborgs Universitet
- Svenska Läkaresällskapet