Pan-genomic characterization and structural variant analysis reveal insights into spore development and species diversity in Ganoderma
Understanding the genomic diversity and functional implications of <i>Ganoderma</i> species is crucial for elucidating their evolutionary history and biotechnological potential. Here, we present the first pan-genomic analysis of <i>Ganoderma</i> spp., combining five newly sequenced genomes with ten publicly available genomes. Our comprehensive comparative study unveiled a rich genomic landscape, identifying core genes shared among all <i>Ganoderma</i> strains and species-specific gene sets. Additionally, we identified structural variants impacting the expression of key genes, including insights into the <i>MSH4</i> gene involved in DNA repair and recombination processes, which exhibits a 440 bp insertion in the promoter region and a leucine-to-serine mutation in the gene body, potentially increasing spore production in the S3 strain. Overall, our study provides valuable insights into the genomic architecture and functional diversity of <i>Ganoderma</i>, paving the way for further research on its evolutionary dynamics, biotechnological applications and pharmaceutical potential.
Authors
- Lin Yu (ORCID: https://orcid.org/0000-0002-1668-4422)
- Zehao Huang (ORCID: https://orcid.org/0000-0003-1653-208X)
- Wen Xu (ORCID: https://orcid.org/0000-0001-7126-8029)
- Lina Wang (ORCID: https://orcid.org/0000-0002-9680-9693)
- Haifeng Wang (ORCID: https://orcid.org/0000-0001-7213-927X)
- Shasha Wang (ORCID: https://orcid.org/0000-0002-2136-6576)
- Xiaoyan Li (ORCID: https://orcid.org/0000-0001-5875-8998)
- Wei Xu (ORCID: https://orcid.org/0000-0001-8675-0934)
- Shuisheng Wu (ORCID: https://orcid.org/0000-0002-6293-6184)
- Hang Yu (ORCID: https://orcid.org/0000-0002-1798-2288)
- Weixin Wu (ORCID: https://orcid.org/0000-0003-3062-6787)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Guangxi University (CN)
Publication Details
- Journal
- Microbial Genomics
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1099/mgen.0.001328
- Citations
- 5
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.24
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Fujian Provincial Department of Science and Technology
- Fujian University of Traditional Chinese Medicine
- Guangxi University
- Science and Technology Planning Project of Fuzhou
- National Key Research and Development Program of China