Rhodium(III)-Catalyzed Regioselective C4 Alkylation of Indoles with Nitroalkenes
The Rh(III)-catalyzed indole C4-H bond addition to nitroalkenes is disclosed under mild and redox-neutral reaction conditions, offering straightforward access to various 4-(2-nitroalkyl)indoles (34 examples) with excellent chemo- and regioselectivity. Furthermore, late-stage diversifications and mechanistic studies were also performed.
Authors
- Liming Zhou (ORCID: https://orcid.org/0000-0002-7700-8794)
- Shuang‐Liang Liu (ORCID: https://orcid.org/0000-0001-8596-3989)
- Shaoming Fang (ORCID: https://orcid.org/0000-0003-0938-9377)
- Zhao Ru
- Lijun Gao (ORCID: https://orcid.org/0000-0002-0123-3805)
- Xulin Lv
- Haoran Yang (ORCID: https://orcid.org/0000-0001-7579-0738)
Institutions
- Zhengzhou University of Light Industry (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1021/acs.joc.4c02236
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Henan Province