A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs
Dogs fed the scFOS+ supplement had decreased total serum IgA concentrations (<i>p</i> < 0.01), which might suggest a more local IgA response in agreement with what was previously found when adult dogs were supplemented with <i>β</i>-1, 3/1, 6-glucan, a yeast-based product. More importantly, the present study demonstrated that feeding 1.1% scFOS+ to healthy senior dogs increased the CD4+:CD8+ T-cell (Helper:Cytotoxic T cell) ratio (<i>p</i> < 0.001) during and after vaccination against Lyme disease. Combining scFOS and yeast-derived postbiotics in the diet can therefore counter certain characteristics of T-cell immunosenescence in dogs.
Authors
- Emmanuelle Apper (ORCID: https://orcid.org/0000-0002-8986-2082)
- Bart J. G. Broeckx (ORCID: https://orcid.org/0000-0001-6742-3911)
- Yang Lyu (ORCID: https://orcid.org/0000-0002-6009-303X)
- Myriam Hesta (ORCID: https://orcid.org/0000-0001-9423-9765)
- Eric Cox (ORCID: https://orcid.org/0000-0003-4281-2990)
- Wendy Wambacq (ORCID: https://orcid.org/0000-0002-4990-5703)
- Michael Pelst (ORCID: https://orcid.org/0000-0002-1779-4738)
- Bert Devriendt (ORCID: https://orcid.org/0000-0002-3222-8769)
- Cindy Le Bourgot (ORCID: https://orcid.org/0000-0001-8478-7020)
- Florence Barbe
Institutions
- Ghent University (BE)
- Lallemand (France) (FR)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2024-11-20
- DOI
- https://doi.org/10.3389/fvets.2024.1392985
- Citations
- 8
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.40