In Vitro and In Vivo Visualization of Perfluorohexyloctane, an Eye Drop for Dry Eye Disease, Using Infrared Emissivity
PFHO quickly spread to form a layer over the surface of saline or meibum in vitro and was detected on the ocular surface in vivo for ≥5 hours after topical administration. This supports findings that PFHO forms a long-lasting barrier to evaporation at the air-liquid interface of the tear film and thus reduces signs and symptoms of DED.
Authors
- Jason L. Vittitow
- Douglas Borchman (ORCID: https://orcid.org/0000-0003-4241-591X)
- T. J. Millar (ORCID: https://orcid.org/0000-0001-5178-3656)
- Simra Ahmed
- Megan E. Cavet
Institutions
- University of Louisville (US)
- Bausch Health (United States) (US)
- Hillrom (Australia) (AU)
Publication Details
- Journal
- Cornea
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1097/ico.0000000000003718
- Citations
- 4
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 2.17