The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy
Topical Rip reduced RGC loss in GL and ON crush, with suppression of ROCK signaling in the retina and ON. The neuroprotection mechanisms appear to involve effects on both RGC and astrocyte responses to IOP elevation.
Authors
- Salaheddine Madhoun (ORCID: https://orcid.org/0000-0001-5395-6397)
- Elizabeth Kimball (ORCID: https://orcid.org/0009-0009-9125-3444)
- Mary Ellen Pease (ORCID: https://orcid.org/0000-0002-1368-1234)
- Harry A. Quigley (ORCID: https://orcid.org/0000-0003-0095-8756)
- Ian Pitha (ORCID: https://orcid.org/0000-0003-2670-9117)
- Thao D. Nguyen (ORCID: https://orcid.org/0000-0002-0312-1583)
- Thomas V. Johnson (ORCID: https://orcid.org/0000-0002-5372-5457)
- Sarah Quillen (ORCID: https://orcid.org/0000-0002-0729-5302)
- Zhuochen Yuan (ORCID: https://orcid.org/0000-0001-6468-784X)
- Liya Du
- Kelsey A. Ritter-Gordy
Institutions
- Johns Hopkins University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1167/iovs.65.13.43
- Citations
- 5
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.69
Funders
- Research to Prevent Blindness
- National Institutes of Health