Contribution of IL-17C-mediated macrophage polarization to Type 17 inflammation in neutrophilic asthma
IL-17C promotes allergic inflammation via M1 polarization of pulmonary macrophages in neutrophilic asthma. Modulation of the IL-17C/IL-17RE axis represents a novel therapeutic target in neutrophilic asthma.
Authors
- Weimin Sun (ORCID: https://orcid.org/0000-0001-9504-031X)
- Junjie Wen
- Kian Fan Chung (ORCID: https://orcid.org/0000-0001-7101-1426)
- Shiyun Xie (ORCID: https://orcid.org/0000-0003-3447-8988)
- Yuhuan Wen (ORCID: https://orcid.org/0000-0002-6425-7281)
- Honglv Chen
- Xiaojing Yang (ORCID: https://orcid.org/0000-0003-0397-2385)
- Wuping Yao (ORCID: https://orcid.org/0009-0009-1402-0700)
- Qingling Zhang (ORCID: https://orcid.org/0000-0002-5287-264X)
- Jie Yan (ORCID: https://orcid.org/0000-0003-2040-5964)
- Ailin Tao (ORCID: https://orcid.org/0000-0003-2223-4572)
- Qile Chen (ORCID: https://orcid.org/0000-0003-2697-8763)
- Le Zhang (ORCID: https://orcid.org/0009-0005-9616-496X)
- Hao Wang (ORCID: https://orcid.org/0009-0008-4494-6793)
Institutions
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou First People's Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-21
- DOI
- https://doi.org/10.1186/s12964-024-01937-8
- Citations
- 11
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.59
Funders
- Guangzhou Medical University
- National Natural Science Foundation of China
- Bureau of Education of Guangzhou Municipality
- Higher Education Discipline Innovation Project