Regulation of disease-associated microglia in the optic nerve by lipoxin B4 and ocular hypertension
We identified early and dynamic changes in the microglia functional phenotype, reactivity, and induction of a unique CD74 microglia population in the distal optic nerve as key features of ocular hypertension-induced neurodegeneration. Our findings establish microglia regulation as a novel LXB<sub>4</sub> target in the retina and optic nerve. LXB<sub>4</sub> maintenance of a homeostatic optic nerve microglia phenotype and inhibition of a disease-associated phenotype are potential neuroprotective mechanisms for the resident LXB<sub>4</sub> pathway.
Authors
- Shruthi Karnam (ORCID: https://orcid.org/0000-0003-1518-380X)
- Jeremy M. Sivak (ORCID: https://orcid.org/0000-0002-8776-223X)
- John G. Flanagan (ORCID: https://orcid.org/0000-0003-1341-1848)
- Tanirika Singh
- Karsten Gronert (ORCID: https://orcid.org/0000-0002-5329-7907)
- Shubham Maurya (ORCID: https://orcid.org/0000-0002-3133-3866)
- Matangi Kumar
- Emily Ward
- Maggie Lin
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Krembil Research Institute
- University of California, Berkeley (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s13024-024-00775-z
- Citations
- 8
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- Glaucoma Research Foundation
- BrightFocus Foundation
- National Eye Institute