Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice
These studies demonstrate a method for empirical identification and preclinical testing of novel neurogenic compounds that can improve BPS and point to possible novel mechanisms that can be interrogated for the development of new therapies to improve specific endophenotypes such as impaired BPS.
Authors
- Angélique Augustin
- Sabrina Golling
- Karly Tegang
- Martin Graf (ORCID: https://orcid.org/0000-0001-5539-5597)
- Holger Fischer (ORCID: https://orcid.org/0000-0002-3807-3438)
- René Hen (ORCID: https://orcid.org/0000-0002-7763-4162)
- Doris Roth (ORCID: https://orcid.org/0000-0003-0411-3945)
- Ravi Jagasia (ORCID: https://orcid.org/0000-0001-9477-7643)
- Indira Mendez‐David (ORCID: https://orcid.org/0000-0001-9759-0833)
- Denis J. David (ORCID: https://orcid.org/0000-0002-0506-6688)
- Sannah Zoffmann (ORCID: https://orcid.org/0009-0000-8631-4462)
- Benjamin A. Samuels (ORCID: https://orcid.org/0000-0003-2535-0376)
- Jens Lamerz
- Luca Santarelli
- Michael Saxe
- Wei-li Chang
- Juergen Wichmann
Institutions
- Rutgers, The State University of New Jersey (US)
- Roche (Switzerland) (CH)
- Biogen (United States) (US)
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris-Saclay (FR)
- Yale University (US)
- New York Psychoanalytic Society and Institute (US)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- New York State Psychiatric Institute
- Columbia University (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1016/j.bpsgos.2024.100419
- Citations
- 6
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.47
Funders
- Hope for Depression Research Foundation
- National Institutes of Health