Serum Metabolomic Profiling of Incident Type 2 Diabetes Mellitus in the Multi-ethnic Study of Atherosclerosis and Rotterdam Study
1H NMR measured metabolites involved in aminoacyl-tRNA biosynthesis, BCAA metabolism, glycolysis/gluconeogenesis, and glycerolipid metabolism were significantly associated with incident T2DM and provided modest to moderate predictive utility beyond traditional risk factors.
Authors
- Alan Kuang (ORCID: https://orcid.org/0000-0001-7991-2835)
- Alain G. Bertoni (ORCID: https://orcid.org/0000-0002-7503-6273)
- Philip Greenland (ORCID: https://orcid.org/0000-0002-6327-2439)
- Yanqiu Zhou (ORCID: https://orcid.org/0000-0002-8462-9177)
- Alexis C. Wood (ORCID: https://orcid.org/0000-0001-7616-2119)
- Carel Wynand le Roux (ORCID: https://orcid.org/0000-0001-5521-5445)
- Marilyn C. Cornelis (ORCID: https://orcid.org/0000-0002-0699-1664)
- Meghana Gadgil (ORCID: https://orcid.org/0000-0001-8638-0048)
- Denise M. Scholtens (ORCID: https://orcid.org/0000-0002-8252-7863)
- Kent D. Taylor (ORCID: https://orcid.org/0000-0002-2756-4370)
- Gonçalo Graça (ORCID: https://orcid.org/0000-0002-0876-3876)
- Fariba Ahmadizar (ORCID: https://orcid.org/0000-0002-6261-9445)
- M. Arfan Ikram (ORCID: https://orcid.org/0000-0003-0372-8585)
- Jerome I. Rotter (ORCID: https://orcid.org/0000-0001-7191-1723)
- Laura J. Rasmussen‐Torvik (ORCID: https://orcid.org/0000-0002-0820-7300)
- Mohsen Ghanbari (ORCID: https://orcid.org/0000-0002-9476-7143)
- Maryam Kavousi (ORCID: https://orcid.org/0000-0001-5976-6519)
- Xihao Du (ORCID: https://orcid.org/0000-0001-6060-3071)
- David M. Herrington (ORCID: https://orcid.org/0000-0002-7670-6400)
- Victor W. Zhong (ORCID: https://orcid.org/0000-0001-9208-4683)
- Jinjun Ran (ORCID: https://orcid.org/0000-0002-2684-6341)
- Ali Farzaneh (ORCID: https://orcid.org/0009-0005-4496-2863)
- Xiuqing Guo (ORCID: https://orcid.org/0000-0002-5264-5068)
- Fang Zhu (ORCID: https://orcid.org/0000-0002-0449-6766)
- Xuanwei Jiang
- Russell P. Tracy
Institutions
- University College Dublin (IE)
- University of Vermont (US)
- Northwestern University (US)
- University of California, San Francisco (US)
- Shanghai Jiao Tong University (CN)
- UCLA Medical Center (US)
- University Medical Center (US)
- University Medical Center Utrecht (NL)
- Cal Humanities (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
- Wake Forest University (US)
- Imperial College London (GB)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1210/clinem/dgae812
- Citations
- 2
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Shanghai Science and Technology Development Foundation
- European Federation of Pharmaceutical Industries and Associations
- European Commission
- National Natural Science Foundation of China
- National Institutes of Health
- National Key Research and Development Program of China
- National Heart, Lung, and Blood Institute