Treatment Intensification With Either Fludarabine, AraC, G-CSF and Idarubicin, or Cladribine Plus Daunorubicin and AraC on the Basis of Residual Disease Status in Older Patients With AML: Results From the NCRI AML18 Trial
In this study of older patients with AML considered fit and with evidence of residual disease after first induction, chemotherapy intensification improved survival. DAC intensification was better tolerated than FLAG-Ida.
Authors
- Steven Knapper (ORCID: https://orcid.org/0000-0002-6405-4441)
- Richard Kelly (ORCID: https://orcid.org/0000-0002-0622-5644)
- Marlen Metzner (ORCID: https://orcid.org/0000-0003-1806-0952)
- Nuria Marquez Almuina
- Abin Thomas (ORCID: https://orcid.org/0000-0002-8283-6762)
- Amanda Gilkes (ORCID: https://orcid.org/0009-0006-2236-8852)
- Sylvie Freeman (ORCID: https://orcid.org/0000-0003-1869-180X)
- Lucy Marsh
- Rob S. Sellar (ORCID: https://orcid.org/0000-0002-0472-7034)
- Nigel H. Russell (ORCID: https://orcid.org/0000-0003-1893-8155)
- Robert K. Hills (ORCID: https://orcid.org/0000-0003-0166-0062)
- Mike Dennis (ORCID: https://orcid.org/0000-0002-2540-8673)
- Priyanka Mehta (ORCID: https://orcid.org/0000-0001-8561-1705)
- Georgia Andrew (ORCID: https://orcid.org/0000-0001-5871-2885)
- Paul Cahalin (ORCID: https://orcid.org/0000-0001-7358-2396)
- Ian Thomas (ORCID: https://orcid.org/0000-0001-9808-0202)
- Ulrik Malthe Overgaard
- Jenny Byrne (ORCID: https://orcid.org/0000-0002-9381-1851)
- Paresh Vyas (ORCID: https://orcid.org/0000-0003-3931-0914)
- Nicholas McCarthy
- Sarah S. Burns (ORCID: https://orcid.org/0000-0002-6907-2366)
Institutions
- University College Hospital (GB)
- North Bristol NHS Trust (GB)
- Nottingham University Hospitals NHS Trust (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- St James's University Hospital (GB)
- Rigshospitalet (DK)
- University College Birmingham (GB)
- University of Oxford (GB)
- National Heart, Lung, and Blood Institute (US)
- MRC Weatherall Institute of Molecular Medicine (GB)
- Blackpool Teaching Hospitals NHS Foundation Trust (GB)
- The Christie NHS Foundation Trust (GB)
- CRUK Lung Cancer Centre of Excellence (GB)
- University College London (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1200/jco.24.00259
- Citations
- 9
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 15.93
Funders
- National Cancer Research Institute
- Cancer Research UK