Dual calcium-voltage optical mapping of regional voltage and calcium signals in intact murine RyR2-R2474S hearts
The pro-arrhythmic <i>RyR2</i>-R2474S/+ phenotype in intact hearts thus directly parallels delayed regional CaT recovery properties and alteration of <i>V</i> <sub>m</sub>-CaT latencies. Studies suggest that discordant localized calcium alternans are mechanistically responsible for action potential duration alternans and occurrence of VT in <i>RyR2</i>-R2474S/+ mice.
Authors
- Christopher Huang (ORCID: https://orcid.org/0000-0001-9553-6112)
- Tangting Chen (ORCID: https://orcid.org/0000-0003-1122-642X)
- Christopher O’Shea (ORCID: https://orcid.org/0000-0003-3030-7364)
- Yangpeng Li
- Xiaoqiu Tan (ORCID: https://orcid.org/0000-0003-0062-6209)
- Xian Luo (ORCID: https://orcid.org/0000-0001-9089-3508)
- Guoliang Hao (ORCID: https://orcid.org/0000-0001-5863-8988)
- Xianhong Ou (ORCID: https://orcid.org/0000-0002-3143-697X)
- Davor Pavlović (ORCID: https://orcid.org/0000-0002-3171-3551)
- Zhu Liu (ORCID: https://orcid.org/0000-0002-0074-1453)
- Jianhong Li (ORCID: https://orcid.org/0009-0005-0373-0740)
- Ming Lei (ORCID: https://orcid.org/0000-0001-9039-7774)
- Weichao Liu (ORCID: https://orcid.org/0000-0003-2623-0907)
Institutions
- University of Cambridge (GB)
- Southwest Medical University (CN)
- University of Oxford (GB)
- Affiliated Hospital of Southwest Medical University (CN)
- University of Birmingham (GB)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1016/j.jmccpl.2024.100121
- Citations
- 3
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Wellcome
- Wellcome Trust
- British Heart Foundation
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- Engineering and Physical Sciences Research Council