Trifluoromethylative and Pentafluoroethylative Heterofunctionalization (C–O, C–S, and C–N) of Alkenes Using Visible Light Photocatalysis
A mild and general method for photoredox-catalyzed trifluoromethylative and pentafluoroethylative heterofunctionalization of alkenes is proposed. In this reaction, the Togni reagent serves as a CF<sub>3</sub>- or CF<sub>2</sub>CF<sub>3</sub>-radical source for the regioselective formation of the C-CF<sub>3</sub> and C-CF<sub>2</sub>CF<sub>3</sub> bonds from alkenes, and additional nucleophiles (O, S, N) provide C-O, C-S, and C-N bonds, respectively. These reactions provide a common gateway to access the fluoroalkylative heterofunctionalization of alkenes.
Authors
- Seongeun Kang
- Ye Rin Choi
- Ki Bum Hong (ORCID: https://orcid.org/0000-0002-4853-2263)
- Hongchan An (ORCID: https://orcid.org/0000-0001-6689-9571)
- Joon Hwang
Institutions
- CHA University (KR)
- Daegu-Gyeongbuk Medical Innovation Foundation (KR)
Publication Details
- Journal
- ACS Omega
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1021/acsomega.4c06017
- Citations
- 4
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.83
Funders
- Korea Institute for Advancement of Technology
- CHA University