Recombination across distant coronavirid species and genera is a rare event with distinct genomic features

Understanding the evolutionary events that led to SARS-CoV-2 emergence, spillover, and spread is crucial to prevent, or at least be prepared for, the same type of occurrence in the future. Given that SARS-CoV-2 has some characteristics not found in other closely related viruses, we aimed to systematically assess how likely these unique features may have been acquired through recombination. We found that, although recombination is a frequent phenomenon among betacoronaviruses, it is mostly limited to closely related members of the same species. Therefore, we conclude that the most likely scenario involved feature acquisition from recombination with a closely related virus that was circulating in a geographically overlapping area or through a different biological process, but not recombination from a virus of a different species, genus, or subgenus.

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Publication Details

Journal
Journal of Virology
Published
2024-11-19
DOI
https://doi.org/10.1128/jvi.01100-24
Citations
1
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.39

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article

Recombination across distant coronavirid species and genera is a rare event with distinct genomic features

Adolfo Garcı́a-Sastre, Jens H. Kuhn, Raúl Rabadán, Juan Ángel Patin͂o-Galindo et al.
1 citations
Journal of Virology
SARS-CoV-2 and COVID-19 Research
0.39
article

Recombination across distant coronavirid species and genera is a rare event with distinct genomic features

Adolfo Garcı́a-Sastre, Jens H. Kuhn, Raúl Rabadán, Juan Ángel Patin͂o-Galindo, Gustavo Palacios
article en
1 citations

Abstract

Understanding the evolutionary events that led to SARS-CoV-2 emergence, spillover, and spread is crucial to prevent, or at least be prepared for, the same type of occurrence in the future. Given that SARS-CoV-2 has some characteristics not found in other closely related viruses, we aimed to systematically assess how likely these unique features may have been acquired through recombination. We found that, although recombination is a frequent phenomenon among betacoronaviruses, it is mostly limited to closely related members of the same species. Therefore, we conclude that the most likely scenario involved feature acquisition from recombination with a closely related virus that was circulating in a geographically overlapping area or through a different biological process, but not recombination from a virus of a different species, genus, or subgenus.

Journal of VirologyVol. 98(12)
National Institutes of Health (US), Department of Mathematical Sciences (RU), National Institute of Allergy and Infectious Diseases (US), Columbia University (US), Icahn School of Medicine at Mount Sinai (US)
U.S. Department of Defense, U.S. Department of Health and Human Services, Pfizer, AstraZeneca, Novavax, PharmaMar, Seqirus, National Institutes of Health, Defense Advanced Research Projects Agency, Advanced Research Projects Agency, National Institute of Allergy and Infectious Diseases, NHLBI Division of Intramural Research
Good health and well-being
Openalex Percentile: Top 35%
SARS-CoV-2 and COVID-19 Research
0.39
DOIOpen Access PDFOpenAlex
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