Exposing 24-hour cycles in bile acids of male humans

Bile acids are trans-genomic molecules arising from the concerted metabolism of the human host and the intestinal microbiota and are important for digestion, energy homeostasis and metabolic regulation. While diurnal variation has been demonstrated in the enterohepatic circulation and the gut microbiota, existing human data are poorly resolved, and the influence of the host circadian system has not been determined. Using entrained laboratory protocols, we demonstrate robust daily rhythms in the circulating bile acid pool in healthy male participants. We identify temporal relationships between bile acids and plasma lipids and show that these relationships are lost following sleep deprivation. We also highlight that bile acid rhythmicity is predominantly lost when environmental timing cues are held constant. Here we show that the environment is a stronger determinant of these temporal dynamics than the intrinsic circadian system of the host. This has significance for the intimate relationship between circadian timing and metabolism.

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Publication Details

Journal
Nature Communications
Published
2024-11-19
DOI
https://doi.org/10.1038/s41467-024-53673-9
Citations
10
Primary Topic
Circadian rhythm and melatonin
Type
article
Field-Weighted Citation Impact
2.74

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article

Exposing 24-hour cycles in bile acids of male humans

Elizabeth A Wimborne, Adesola T. Bello, Debra J. Skene, Jonathan R. Swann et al.
10 citations
Nature Communications
Circadian rhythm and melatonin
2.74
article

Exposing 24-hour cycles in bile acids of male humans

Elizabeth A Wimborne, Adesola T. Bello, Debra J. Skene, Jonathan R. Swann, Florence I. Raynaud, Daan R. van der Veen, Victoria L. Revell, Magali Sarafian, Namrata R. Chowdhury, Benita Middleton
article en
10 citations

Abstract

Bile acids are trans-genomic molecules arising from the concerted metabolism of the human host and the intestinal microbiota and are important for digestion, energy homeostasis and metabolic regulation. While diurnal variation has been demonstrated in the enterohepatic circulation and the gut microbiota, existing human data are poorly resolved, and the influence of the host circadian system has not been determined. Using entrained laboratory protocols, we demonstrate robust daily rhythms in the circulating bile acid pool in healthy male participants. We identify temporal relationships between bile acids and plasma lipids and show that these relationships are lost following sleep deprivation. We also highlight that bile acid rhythmicity is predominantly lost when environmental timing cues are held constant. Here we show that the environment is a stronger determinant of these temporal dynamics than the intrinsic circadian system of the host. This has significance for the intimate relationship between circadian timing and metabolism.

Nature CommunicationsVol. 15(1)
Institute of Cancer Research (GB), University of Surrey (GB), BIOASTER (FR), University of Southampton (GB), Imperial College London (GB)
National Institute for Health and Care Research, University of Surrey, National Institute for Health Research Southampton Biomedical Research Centre, Directorate for Biological Sciences, Medical Research Council, Biotechnology and Biological Sciences Research Council
Openalex Percentile: Top 10%
Circadian rhythm and melatonin
2.74
DOIOpen Access PDFOpenAlex
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