Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy
PDGF signaling led to increased proliferation and activation of TED OFs. Treatment of TED OFs with the AHR ligands, FICZ and tapinarof, mitigated PDGF induced effects. These studies support the concept that AHR and PDGF signaling could form the basis for new TED therapeutics.
Authors
- Collynn F. Woeller (ORCID: https://orcid.org/0000-0001-7197-5057)
- C. Patrick (ORCID: https://orcid.org/0000-0002-3267-0733)
- Steven E. Feldon (ORCID: https://orcid.org/0000-0003-0603-9312)
- Farha Husain
- Elisa Roztocil
Institutions
- University of Rochester Medical Center (US)
- University of Rochester (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1167/iovs.65.13.40
- Citations
- 5
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- Research to Prevent Blindness
- National Institutes of Health