An unconventional purine connection
Xu et al. (https://doi.org/10.1084/jem.20240354) define NAD-induced cell death via purinergic P2RX7 receptor in type 1 unconventional T cells, particularly intrahepatic MAIT cells that are pivotal in liver homeostasis. Therefore, P2RX7 is a potential target to modulate unconventional T cells in immunopathological conditions and cancer.
Authors
- Fabio Grassi (ORCID: https://orcid.org/0000-0003-3348-1712)
Institutions
- University of Milan (IT)
- Mylan (Switzerland) (CH)
- Istituto Nazionale Genetica Molecolare (IT)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1084/jem.20241527
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.24