Antimicrobial polyketides from an endophytic fungus <i>Arcopilus aureus</i> HJ-7 from <i>Ardisia mamillata</i> Hance

Eleven polyketide derivatives, including two new compounds, xanthoradone D (<b>1</b>) and arisochromophilone (<b>2</b>), were isolated from <i>Arcopilus aureus</i> HJ-7, a Chinese medicinal plant <i>Ardisia mamillata</i> Hance-associated fungus. Their structures were elucidated on the basis of spectroscopic analysis and ECD (Electronic Circular Dichroism) calculations. The antibacterial and antifungal activities of the compounds were evaluated. Compound <b>1</b> showed the significant inhibitory activity against <i>Staphylococcus aureus</i> and <i>Xanthomonas axonopodis pv.</i> citri (Hasse) Dye with the MIC (Minimum Inhibitory Concentration) value of 6.25 μg/mL, and <b>1</b> also showed strong antifungal activities against <i>Cochliobolus miyabeanus</i> and <i>Ceratocystis paradoxa</i> with the MIC value of 3.125 μg/mL.