Unveiling the molecular mechanisms of Danggui-Shaoyao-San against Alzheimer’s disease in APP/PS1 mice via integrating proteomic and metabolomic approaches
Our study is the first to integrate multi-omics approaches to reveal that DSS could regulate the GSK3β/PGC1α signalling pathway to exert therapeutic effects in AD through the promotion of EM, thereby providing new insights into the mechanism of action of DSS against AD.
Authors
- Jinman Liu (ORCID: https://orcid.org/0000-0002-6421-7482)
- Mao-Zhong Yao
- Jiansong Fang (ORCID: https://orcid.org/0000-0002-6998-5384)
- Guohu Weng
- Chuipu Cai (ORCID: https://orcid.org/0000-0002-6778-9697)
- Wei Wang (ORCID: https://orcid.org/0000-0001-5401-3331)
- Yong Gu (ORCID: https://orcid.org/0000-0002-4444-9382)
- Zigui Huang (ORCID: https://orcid.org/0009-0003-4438-0885)
- Weirong Li (ORCID: https://orcid.org/0000-0002-3878-8724)
- Hongying Li (ORCID: https://orcid.org/0009-0006-4374-2524)
- Xianghao Lin (ORCID: https://orcid.org/0009-0004-0541-9561)
- Qihui Wu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shantou University (CN)
- Hubei University of Science and Technology (CN)
- Hainan Center for Disease Control & Prevention (CN)
- Jiangmen Central Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s13195-024-01618-1
- Citations
- 15
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.51
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province