Solid-State Gas Sensors with Ni-Based Sensing Materials for Highly Selective Detecting NOx

Precise monitoring of NO_x concentrations in nitric oxide delivery systems is crucial to ensure the safety and well-being of patients undergoing inhaled nitric oxide (iNO) therapy for pulmonary arterial hypertension. Currently, NO_x sensing in commercialized iNO instruments predominantly relies on chemiluminescence sensors, which not only drives up costs but also limits their portability. Herein, we developed solid-state gas sensors utilizing Ni-based sensing materials for effectively tracking the levels of NO and NO₂ in the NO delivery system. These sensors comprised of NiO-SE or (NiFe₂O₄ + 30 wt.% Fe₂O₃)-SE vs. Mn-based RE demonstrated high selectivity toward 100 ppm NO under the interference of 10 ppm NO₂ or 3 ppm NO₂ under the interference of 100 ppm NO, respectively. Meanwhile, excellent stability, repeatability, and humidity resistance were also verified for the proposed sensors. Sensing mechanisms were thoroughly investigated through assessments of adsorption capabilities and electrochemical reactivity. It turns out that the superior electrochemical reactivity of NiO toward NO, alongside the NO₂ favorable adsorption characteristics of (NiFe₂O₄ + 30 wt.% Fe₂O₃), is the primary reason for the high selectivity to NO_x. These findings indicate a bright future for the application of these NO_x sensors in innovative iNO treatment technologies.