Glutaminolysis is associated with mitochondrial pathway activation and can be therapeutically targeted in glioblastoma
Our findings confirm that glioblastoma tissues can be categorized into glycolytic-dominant and mitochondrial-dominant types, as previously reported. The mitochondrial-dominant type is also glutaminolysis-dominant. Therefore, inhibiting the glutaminolysis pathway may be an effective treatment for mitochondrial-dominant glioblastoma.
Authors
- Nayuta Higa (ORCID: https://orcid.org/0000-0001-8853-8769)
- Yuhei Sangatsuda (ORCID: https://orcid.org/0000-0002-0914-4305)
- Daisuke Kuga (ORCID: https://orcid.org/0000-0002-9493-0748)
- Ryosuke Otsuji (ORCID: https://orcid.org/0000-0001-7177-663X)
- Akihide Tanimoto
- Daiki Setoyama (ORCID: https://orcid.org/0000-0002-4514-7546)
- Koji Yoshimoto (ORCID: https://orcid.org/0000-0001-7912-2024)
- Takeshi Uchiumi (ORCID: https://orcid.org/0000-0002-3665-233X)
- Yutaka Fujioka (ORCID: https://orcid.org/0000-0002-8506-9343)
- Yuya Kunisaki (ORCID: https://orcid.org/0000-0003-0141-7038)
- Ryosuke Hanaya (ORCID: https://orcid.org/0000-0002-4170-4878)
- Toshiaki Akahane
- Ryusuke Hatae (ORCID: https://orcid.org/0000-0001-5636-8064)
- Tomoko Takajo
- Mikako Yagi
- Kenji Miki (ORCID: https://orcid.org/0000-0001-7424-0021)
- Takahiro Miyazaki
- K. Goto
- Yonezawa Hajime
Institutions
- Kagoshima University (JP)
- Kyushu University (JP)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s40170-024-00364-0
- Citations
- 6
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Fukuoka Public Health Promotion Organization Cancer Research Fund
- Japan Society for the Promotion of Science