Quantification of [99mTc]Tc-HDP bone SPECT/CT: can we improve the body weight based standardized uptake value with a more robust normalization?
Using an age, bone density and weight-based normalization significantly decreased the interindividual variability of normal uptake on quantitative SPECT/CT compared to the regularly used BW adjusted SUV<sub>BW</sub>. However, a generalized normalization is difficult in the presence of strong patient effects, not attributable to the measured clinical variables.
Authors
- Jakob Heimer (ORCID: https://orcid.org/0000-0003-3499-8801)
- R. Huch (ORCID: https://orcid.org/0000-0002-3636-8697)
- Daniel Hausmann (ORCID: https://orcid.org/0000-0002-3816-3302)
- Irene A. Burger (ORCID: https://orcid.org/0000-0001-8029-8692)
- Cristina Popescu (ORCID: https://orcid.org/0000-0002-0350-7187)
- Alexander Sauter (ORCID: https://orcid.org/0000-0002-6707-2258)
- Karim Eid (ORCID: https://orcid.org/0000-0002-1140-2983)
- Noel Spielhofer
- Tiberiu Damian (ORCID: https://orcid.org/0009-0007-0980-9665)
- Jason L. Manser
Institutions
- University of Zurich (CH)
- ETH Zurich (CH)
- University Hospital of Zurich (CH)
- University of Tübingen (DE)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s13550-024-01167-6
- Citations
- 1
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Siemens Healthineers