Low-Dose Ketone Monoester Administration in Adults with Cystic Fibrosis: A Pilot and Feasibility Study
With the emerging role of exogenous ketones as nutrient signaling molecules and mediators of metabolism, we showed that KME is well tolerated, increases circulating D-βHB concentrations, and produces outcomes that justify the need for large-scale clinical trials to investigate the role of KME on whole-body and tissue lipid accumulation and inflammation in pwCF.
Authors
- Jonathan M. Bergeron
- Kevin R. Fontaine (ORCID: https://orcid.org/0000-0002-2807-6440)
- Amit Gaggar (ORCID: https://orcid.org/0000-0003-1586-5632)
- Heather Hathorne
- Jessica A. Alvarez (ORCID: https://orcid.org/0000-0002-7612-1162)
- Kristopher R. Genschmer (ORCID: https://orcid.org/0000-0002-1836-9522)
- Anastasia Hartzes
- Amy Miskimon Goss (ORCID: https://orcid.org/0000-0001-8772-2935)
- Mickey L. Bolyard
- Eric P. Plaisance (ORCID: https://orcid.org/0000-0001-9621-6583)
- Christina M. Graziano (ORCID: https://orcid.org/0009-0009-6586-3548)
Institutions
- Emory University (US)
- University of Utah (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Nutrients
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3390/nu16223957
- Citations
- 3
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.26