Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies
Randomization is 2:1 to enoxaparin or usual care (no enoxaparin) for older children and 1:1:1 to either of 2 anti-Xa ranges of enoxaparin or usual care for infants. Ultrasonography will be performed after removal of CVC to assess for CADVT. Subjects will be monitored for bleeding. Platelet poor plasma will be analyzed for markers of thrombin generation. Samples from subjects with CADVT will be counter-matched 1:1 to subjects without CADVT from the opposite trial arm. Institutional Review Board approved the "CRETE Studies" on July 1, 2021. Enrollment is ongoing with planned completion in July 2025 for older children and July 2026 for infants.
Authors
- Lee Polikoff
- Madhuradhar Chegondi (ORCID: https://orcid.org/0000-0002-1375-6988)
- Sarah Kandil (ORCID: https://orcid.org/0000-0002-2618-2119)
- Philip Charles Spinella (ORCID: https://orcid.org/0000-0003-1721-0541)
- Anthony A. Sochet (ORCID: https://orcid.org/0000-0002-6290-4975)
- Anjali Sharathkumar (ORCID: https://orcid.org/0000-0003-4574-6175)
- Sarah N. Taylor (ORCID: https://orcid.org/0000-0002-6948-8329)
- Matthew K. Leroue (ORCID: https://orcid.org/0000-0001-7585-7920)
- Amanda Kolmar (ORCID: https://orcid.org/0000-0002-4703-2937)
- Teddy Muisyo
- Christie Glau (ORCID: https://orcid.org/0000-0003-1583-4609)
- Marianne E. Nellis (ORCID: https://orcid.org/0000-0002-2697-6314)
- Leslie Raffini (ORCID: https://orcid.org/0000-0001-8152-1040)
- Hilary Schreiber
- E. Vincent S. Faustino (ORCID: https://orcid.org/0000-0001-6155-2691)
- Lauren Ehrlich
- Jill M. Cholette
- Michelle Ramírez (ORCID: https://orcid.org/0000-0002-8888-7720)
- Michele Kong (ORCID: https://orcid.org/0000-0001-6596-3965)
- Tara McPartland
- Oscar M. Navarro (ORCID: https://orcid.org/0000-0001-8910-0304)
- Elizabeth Kerris
- Veronika Shabanova (ORCID: https://orcid.org/0000-0001-8090-9238)
- Matthew G. Pinto
- Cicero T. Silva
Institutions
- University of Iowa (US)
- Children's Hospital of Philadelphia (US)
- Johns Hopkins University (US)
- University of Pittsburgh (US)
- University of Toronto (CA)
- Medical College of Wisconsin (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Brown University (US)
- Hospital for Sick Children (CA)
- University of Alabama at Birmingham (US)
- Yale University (US)
- NYU Langone Health (US)
- Institute for Transfusion Medicine (US)
- Johns Hopkins All Children's Hospital (US)
- Maria Fareri Children's Hospital (US)
- Children's Hospital of Oklahoma (US)
- University of Oklahoma Health Sciences Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Rochester (US)
- Penn State Milton S. Hershey Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Pediatric Critical Care Medicine
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1097/pcc.0000000000003648
- Citations
- 5
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- University of South Carolina
- Novavax
- Children's Hospital Association
- National Institutes of Health
- National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development