Copper-Catalyzed Cascade Cyclization of 2-Nitrochalcones with NH-Heterocycles
We developed a method for allowing cascade cyclization of 2-nitrochalcones with pyrazoles, imidazole, and indazole in the presence of CuI catalyst, DBU base, and THF solvent. The conditions were tolerant of an array of useful functionalities including ester, nitro, cyano, halogen groups. A mechanistic consideration was also provided, as H<sub>2</sub>O<sub>2</sub> was presumably a byproduct. Our method appears to be a rare example to directly prepare C3-heterocyclic unprotected indoles.
Authors
- Tung Thanh Nguyen (ORCID: https://orcid.org/0000-0002-0912-9981)
- Thang M. Ly (ORCID: https://orcid.org/0000-0002-4839-9829)
- Tan N. Huynh
- Nam Phan (ORCID: https://orcid.org/0000-0003-1506-5440)
- Phuong Dinh (ORCID: https://orcid.org/0009-0004-4118-1933)
Institutions
- Vietnam National University Ho Chi Minh City (VN)
- Ho Chi Minh City University of Technology (VN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1021/acs.joc.4c01960
- Citations
- 5
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- University of Science Ho Chi Minh City