Peripheral pnet of the inguinal region with favorable response to QT-Thalidomide Neoadjuvant

Introduction: PNETs are neoplasms derived from the neural crest. They are classified into: 1) central PNET, 2) neuroblastoma and 3) peripheral PNET. The objective is to report the case of a 32-year-old female patient with an inguinal tumor with immunohistochemical profile compatible for PNET treated with chemotherapy and induction thalidomide. Case presentation: 32-year-old female patient presented with a tumor in the inguinal region, the biopsy indicated: round cell neoplasm with small nuclei, hyperchromatic and monomorphous; the immunohistochemical profile was synaptophysin positive, neurofilament positive, SOX-11 positive and Ki-67: 70%, induction chemotherapy was started with carboplatin- etoposide and thalidomide achieving a 60% reduction in tumor size, followed by compartmentectomy with regional lymphadenectomy and later adjuvant radiotherapy and maintenance chemotherapy. Conclusions: In this patient, multidisciplinary treatment for pPNET benefited from the use of chemotherapy and thalidomide in the induction phase.