Silibinin-Loaded Liposomes: The Influence of Modifications on Physicochemical Characteristics, Stability, and Bioactivity Associated with Dermal Application
Silibinin-loaded liposomes (MLVs and lyophilized) showed promising antioxidant activity (toward reactive oxygen species generated in cells) and anti-inflammatory effects (reducing macrophage inhibitory factor expression) on keratinocytes and did not lead to a change in their viability. Future perspectives will focus on wound healing, anti-aging, and other potential of developed liposomes with silibinin in sophisticated cell-based models of skin diseases, wounds, and aging.
Authors
- Bojan Stojadinović (ORCID: https://orcid.org/0000-0002-2711-8821)
- Andrea Pirković (ORCID: https://orcid.org/0000-0002-1182-4895)
- Katarina Šavikin (ORCID: https://orcid.org/0000-0002-2086-9593)
- Аleksandar Marinković (ORCID: https://orcid.org/0000-0003-3239-5476)
- Aleksandra Jovanović (ORCID: https://orcid.org/0000-0001-5394-0125)
- Milena Milošević (ORCID: https://orcid.org/0000-0002-4949-5062)
- Amjed Karkad
Institutions
- University of Belgrade (RS)
- Institute for Plant Protection and Environment (RS)
- University Elmergib (LY)
- Institute of Physics Belgrade (RS)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3390/pharmaceutics16111476
- Citations
- 6
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.25