IL-37 suppresses CNS autoimmunity by increasing the frequency of Treg cells and reducing CD4 + T cell-derived IL-10 production
Our findings confirm the immunomodulatory role of IL-37 in CNS inflammation during ongoing disease, thus indicating the potential of IL-37 as an inhibitory reagent for MS therapy.
Authors
- Reza Yazdani (ORCID: https://orcid.org/0000-0002-3760-4137)
- Amir Moghadam Ahmadi (ORCID: https://orcid.org/0000-0003-2756-1265)
- Hamed Naziri (ORCID: https://orcid.org/0000-0001-6290-8944)
- Bogoljub Ćirić (ORCID: https://orcid.org/0000-0001-5361-7635)
- Abdolmohamad Rostami (ORCID: https://orcid.org/0000-0003-0716-2726)
- Gholamreza Azizi (ORCID: https://orcid.org/0000-0001-5658-2511)
- Jaya Aseervatham (ORCID: https://orcid.org/0000-0002-0160-0951)
- Mozhde Askari (ORCID: https://orcid.org/0000-0003-3055-3389)
- Guang-Xian Zhang
Institutions
- Thomas Jefferson University (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s12974-024-03295-1
- Citations
- 5
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- National Institutes of Health